The combination of EWSR1-FLI1 and loss of one EWSR1 allele leads to the induction of trisomy 8
Harsha Hapugaswatta, Alejandro Parrales, Hyewon Park, Haeyoung Kim, Tomoo Iwakuma, Mizuki Azuma
This paper shows that EWSR1-FLI1 fusion and loss of one EWSR1 allele induce trisomy 8 through disruption of the EWSR1-Aurora B pathway.
bioRxiv · May 24, 2026 · PreprintCancer Biology