The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle.
Ashok Daniel Prabakaran, Hyun-Jy Chung, Kevin McFarland, Thirupugal Govindarajan, F. E. A. Soussi, Hima Bindu Durumutla, Chiara Villa, Kevin Piczer, Hannah Latimer, Cole Werbrich, Olukunle Akinborewa, Robert Horning, Mattia Quattrocelli
This study identifies Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle, using a human SNP rs6190 in mice and human datasets.
Science Advances · Jul 9, 2025Peer-reviewedPhysiology