Desktop-Scale Hit-Point Discovery for Intrinsically Disordered α-Synuclein Using State-Space Compression and a Discrete Phase-Interference Search Operator
Dae Hoon Kim, Gerelt-Od Khenmedekh, I Y Park, Sangjune Kim
The paper introduces a drug discovery engine that efficiently narrows down chemical space for α-synuclein inhibitors using state-space compression and a novel search operator, achieving high inhibition rates in assays.
bioRxiv · Jun 28, 2026 · PreprintBioinformatics