Sangjune Kim

The paper introduces a drug discovery engine that efficiently narrows down chemical space for α-synuclein inhibitors using state-space compression and a novel search operator, achieving high inhibition rates in assays.

This study investigates the effects of Gba1 E326K mutation in mice, showing increased microglia activation, neuroinflammation, and dopaminergic neurodegeneration.

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.