The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach
I. A. Rodriguez-Brenes, N. Komarova, D. Wodarz
The paper models the role of telomere shortening in cancer emergence using a hybrid stochastic-deterministic approach, finding that cell death rates and p53 mutant division capacity influence the likelihood of double mutations in telomere-induced instability.
bioRxiv · Nov 13, 2017Cancer Biology