N. Komarova

Two modes in the velocity statistics in cautious walks of laboratory rodents

This paper analyzes rodent movement patterns in open-field tests, finding two velocity modes and proposing a stochastic model to explain their behavior.

Deterministic approximation for population dynamics in the presence of advantageous mutants

The paper develops a deterministic approximation for spatial stochastic birth-death processes with two types, showing good agreement with stochastic simulations and applicability to selective sweep events.

Effect of human behavior on the evolution of viral strains during an epidemic

The paper models how human behavioral changes during an epidemic can drive the evolution of more asymptomatic viral strains.

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

The role of migration in mutant evolution in fragmented populations

This study investigates how migration affects mutant distribution in fragmented populations, showing that migration alters probability distributions and can sustain mutant numbers in small demes.

The protective effect of aspirin in colorectal carcinogenesis: a multiscale computational study from mutant evolution to age incidence curves

This study uses mathematical models to show that aspirin-induced changes in tumor cell fitness can explain reduced colorectal adenoma incidence in treated patients.

Evolutionary dynamics of culturally transmitted, fertility-reducing traits

The paper models how reduced mortality can directly cause a decline in fertility through cultural transmission of low fertility traits, explaining demographic transitions in Western Europe.

Mutant evolution in spatially structured and fragmented populations

This study shows that mutant evolution in spatially structured populations depends on population fragmentation rather than spatial structure, with different scaling laws for mutant abundance based on fitness and dimensionality.

The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach

The paper models the role of telomere shortening in cancer emergence using a hybrid stochastic-deterministic approach, finding that cell death rates and p53 mutant division capacity influence the likelihood of double mutations in telomere-induced instability.

Passenger mutations can accelerate tumor suppressor gene inactivation in cancer evolution

The paper shows passenger mutations can speed up tumor suppressor gene inactivation by reducing population fitness and increasing intermediate mutant fitness during cancer evolution.