FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation
E. Fasana, I. Fregno, C. Galli, M. Molinari
The paper shows that ERLAD compensates for ERAD dysfunction by delivering misfolded proteins to lysosomes when ERAD is inhibited.
bioRxiv · Nov 28, 2023 · PreprintCell Biology