M. Molinari

ER-phagy Receptors Intrinsically Disordered Modules Drive ER Fragmentation and ER-phagy

This study shows that intrinsically disordered regions (IDRs) of ER-phagy receptors drive ER fragmentation, not their membrane-remodeling domains.

TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44

The paper identifies TMX5 as a PDI family member that interacts with ERp44 via disulfide bonds, controlling its ER retention and distribution.

N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation

This study shows N-formylation of PSM3 affects its membrane interactions and self-assembly, leading to membrane damage through intermediate protofibrillar entities.

FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation

The paper shows that ERLAD compensates for ERAD dysfunction by delivering misfolded proteins to lysosomes when ERAD is inhibited.

Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells

This study shows that knocking out UGGT1 or UGGT1/2 genes rescues secretion of a misfolded Trop-2 glycoprotein mutant in mammalian cells.

SEC62 and TMX4 control asymmetric autophagy of the nuclear envelope upon LINC complex disassembly

The paper identifies SEC62 and TMX4 as regulators of asymmetric autophagy of the nuclear envelope during LINC complex disassembly in response to ER homeostatic changes.

Extracellular Vesicles Hijack the Autophagic Pathway to Induce Tau Accumulation in Endolysosomes

This study shows extracellular vesicles deliver Tau seeds to endolysosomes, where autophagy promotes Tau accumulation and cytotoxicity, suggesting autophagy stimulation may worsen tauopathies.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import