Integrin α6β4 recognition of a linear motif of bullous pemphigoid antigen BP230 controls its recruitment to hemidesmosomes
J. A. Manso, M. Gomez-Hernandez, A. Carabias, N. Alonso-Garcia, I. Garcia-Rubio, M. Kreft, A. Sonnenberg, J. M. de Pereda
The paper identifies a linear motif in BP230 that binds to integrin β4, essential for hemidesmosome assembly, and shows that disrupting this interaction prevents BP230 recruitment.
bioRxiv · Dec 20, 2018Biophysics