TRIM 25 nuclear translocation is hampered by localization to influenza A virus non-structural protein 1 cytosolic aggregates
S. Kummer, A. Weiss, I. Haralampiev
This study shows TRIM25 is localized to cytosolic NS1 aggregates in IAV-infected cells, impairing its nuclear translocation and affecting IRF3 activation, with strain-dependent differences observed.
bioRxiv · Oct 10, 2022 · PreprintMicrobiology