A. Weiss

SSR42 is a Novel Regulator of Cytolytic Activity in Staphylococcus aureus

This paper identifies SSR42 as a novel regulatory RNA in S. aureus that enhances cytotoxicity and virulence by modulating lukAB expression through RNA-RNA interactions.

Intestinal tissue response to Shiga toxin exposure

This study investigates how human intestinal epithelial and mesenchymal cells interact during Shiga toxin exposure, showing that mesenchymal cells contribute to epithelial cell death and that epithelial cells are more resistant to toxin exposure.

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCA H1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

This study develops a zebrafish model of glioblastoma driven by specific oncogenic variants and shows inflammation inhibits tumor growth during initiation and relapse.

Conditional Requirement for Dimerization of the Membrane-Binding Module of BTK

This study investigates whether BTK dimerization via its PH-TH module is required for signaling in B and T cells, finding it is not necessary in B cells but essential in T cells.

Discovery of the gut microbial enzyme responsible for bilirubin reduction to urobilinogen

This study identifies BilR, a gut microbial enzyme that reduces bilirubin to urobilinogen, and shows its prevalence in healthy adults and decline in neonates and IBD patients.

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness

The study shows that prolonged TCR signaling from self-antigens in naive CD8 T cells reduces their responsiveness to foreign antigens through gene expression changes and negative regulators like Sts1 and Cbl-b.

TRIM 25 nuclear translocation is hampered by localization to influenza A virus non-structural protein 1 cytosolic aggregates

This study shows TRIM25 is localized to cytosolic NS1 aggregates in IAV-infected cells, impairing its nuclear translocation and affecting IRF3 activation, with strain-dependent differences observed.

Glutathione-mediated plant response to high-temperature

This study investigates how glutathione mediates plant responses to high-temperature stress, showing its role in redox regulation and adaptation to heat.

Naive arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen

This study identifies a defect in anergy and a biased TCR repertoire in naive arthritogenic SKG CD4 T cells, driven by endogenous viral superantigens, leading to autoimmune arthritis.

Intestinal Enteroid Monolayers Model the Human Intestinal Environment for Escherichia coli Infection

This study uses human intestinal enteroid monolayers to model O157:H7 infection, showing that O157:H7 adheres and damages the epithelium while commensal E. coli does not.

Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1

The paper shows that P-TEFb assembly and levels depend on reversible phosphorylation of cyclinT1 by PKC and dephosphorylation by PP1, leading to P-TEFb disassembly and CycT1 degradation in quiescent and terminally differentiated cells.

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant

This study shows niclosamide is effective against SARS-CoV-2 and its variants in a human airway model, supporting its potential as a COVID-19 therapy.

Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

This study quantifies motor phenotypes caused by ASOs in the CNS and identifies modifications that reduce toxicity while maintaining efficacy.

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

This study identifies Itk-mediated phosphorylation sites on SLP-76 and Gads that regulate TCR/CD28 costimulation-induced transcriptional responses.

Therapeutic assessment of targeting ASNS combined with L-Asparaginase treatment in solid tumors and investigation of resistance mechanisms

This study assesses targeting ASNS with L-Asparaginase in solid tumors, identifies resistance mechanisms, and proposes therapeutic combinations.

Spatially-targeted proteomics of the host-pathogen interface during staphylococcal abscess formation

The paper uses spatially targeted proteomics to analyze host-pathogen interactions during staphylococcal abscess formation, identifying immune responses and bacterial contributions across different abscess regions.

Personality, Subjective Well-Being, and the Serotonin 1a Receptor Gene in Common Marmosets (Callithrix jacchus)

The study examines personality traits in common marmosets, identifying multiple factors and their relationship with well-being, but finds no genetic associations.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.

Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization

The paper identifies a switch-like PIP3 sensing mechanism in Btk's PH-TH module that enhances sensitivity through dimerization and multiple PIP3 binding.

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

The paper develops a high-throughput method to map tyrosine kinase specificities and identifies differences in substrate recognition between Lck and c-Src.