Author

I. K. Schaeffner

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Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. E. Heppner· 1 shared J. K. Rana· 1 shared M. J. Eck· 1 shared T. S. Beyett· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperPharmacology & Toxicology

D. E. Heppner

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1 paper

Recent·Most cited

Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase

T. S. Beyett, J. K. Rana, I. K. Schaeffner, D. E. Heppner, M. J. Eck

The paper analyzes the structural basis of BI-4020's selectivity and potency against mutant EGFR by combining biochemical assays and X-ray crystallography.

bioRxiv · Aug 27, 2022Pharmacology & Toxicology