Synonymous codon substitutions perturb co-translational protein folding in vivo and impair cell fitness
I. M. Walsh, M. A. Bowman, I. F. Soto, A. Rodriguez, P. L. Clark
This study shows that synonymous codon substitutions affect co-translational protein folding, leading to reduced cell fitness despite normal enzyme activity.
bioRxiv · Sep 13, 2019Biochemistry