A. Rodriguez

Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice

This study shows that CD163 deficiency in obese male mice worsens insulin sensitivity by promoting inflammation and iron dysregulation in adipose tissue macrophages.

Cell-scale porosity in microporous annealed particle (MAP) scaffolds modulates immune response and promotes formation of innervated muscle fibers in volumetric muscle loss injuries

This study shows that cell-scale porosity in MAP scaffolds improves muscle regeneration in VML injuries by modulating immune response and supporting innervated muscle fiber formation.

Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma

This study identifies enasidenib as an effective treatment for IDH2 mutant chondrosarcoma through personalized medicine approaches involving sequencing, cell line models, and in vitro/in vivo testing.

Do seabirds dream of artificial lights? Understanding light preferences of Procellariiformes

This study investigates light preferences of Corys shearwater fledglings and adults, finding a preference for no-light and red light, suggesting artificial light disorients seabirds.

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

The paper identifies microbiome biomarkers and a gut-nasopharyngeal microbiota ratio that predict severe COVID-19 outcomes.

Prediction of myeloid malignant cells in Fanconi anemia using machine learning

This study uses machine learning to identify myeloid malignant transcriptional profiles in FA patients' bone marrow using scRNAseq data, achieving high sensitivity and specificity for MDS and AML detection.

The unusual structural properties and potential biological relevance of switchback DNA

This study characterizes switchback DNA, a left-handed DNA structure, showing its unique stability, nuclease resistance, and potential biological role in tandem repeats.

Downregulation of Let-7 miRNA promotes Tc17 differentiation and emphysema via de-repression of RORγt

This study shows that downregulation of let-7 miRNA promotes Tc17 differentiation and emphysema by de-repressing RORγt in mice.

The Hsp60 C-terminus Senses Substrate and Triggers Allosteric ATP Hydrolysis

This study shows that the C-terminal tail of Hsp60 senses substrate and triggers allosteric ATP hydrolysis, revealing the mechanism of substrate-dependent ATP hydrolysis in the chaperonin.

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

The paper identifies two new divisome members in Corynebacteriales and shows their role in coordinating cell division and polar elongation with the divisome and elongasome.

Diel activity patterns of vector mosquito species in the urban environment: Implications for vector control strategies

This study assesses diel activity patterns of mosquito species in Miami-Dade and Brownsville and evaluates the effectiveness of adulticide treatments at different times of day.

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

The global distribution and environmental drivers of the soil antibiotic resistome

This study maps the global distribution of antibiotic resistance genes in soils and identifies key environmental drivers influencing their prevalence.

Characterization of an ant colony (Paraponera clavata) during rest and relocation phases: an experimentally induced protocol

The paper studies social roles and labor distribution in ant colonies during rest and relocation phases using an experimentally induced protocol and behavioral analysis.

Bladder cancer organoids as a functional system to model different disease stages and therapy response

This study uses bladder cancer patient-derived organoids to model disease stages and therapy response, identifying markers of resistance and sensitivity.

Structural basis of flagellar filament asymmetry and supercoil templating by Leptospira spirochete sheath proteins

This study solves cryo-EM structures of Leptospira flagellar filaments, revealing how sheath proteins induce supercoiling and motility through distinct functional roles.

Novel Fusarium Wilt Resistance Genes Uncovered in the Wild Progenitors and Heirloom Cultivars of Strawberry

This study identifies multiple resistance genes against Fusarium wilt in wild and cultivated strawberries and develops markers for breeding resistant cultivars.

Harbingers of Aggressive Prostate Cancer: Precision Oncology Case Studies

This study identifies molecular features of primary prostate cancer and their relation to metastasis using genomic and histopathological analysis.

Effect of landscape structure on genetic structure of the Lesser horseshoe bat (Rhinolophus hipposideros) in Britanny colonies

The paper examines how landscape structure affects the genetic structure of Lesser horseshoe bats in Brittany by analyzing genetic and ecological distances between colonies.

A comprehensive, FAIR file format for neuroanatomical structure modeling

The paper describes a FAIR-compliant file format for neuroanatomical structure modeling and its updates to support data reuse and interoperability.

Differences in personality / temperament in the endangered tortoise Testudo hermanni and their implications on dispersal and conservation

The paper examines personality differences in Hermann tortoises to inform conservation strategies by linking temperament to dispersal behaviors.

Global change affects differently at local scales animal populations: why Starlings still expands to the south while other temperate species go to the north?

The paper examines why European starlings expand southward while other temperate birds move northward in response to global warming, focusing on differences in reproductive timing and distribution shifts.

Habituation, task solving and memorization may facilitate biological invasions: the Starling example

This study examines how habituation, task solving, and memorization in European starlings may enhance their ability to invade new environments.

Population colonization history influences behavioral responses of European starlings in personality tests

This study examines how colonization history affects behavioral responses to novelty in European starlings, finding differences in anxiety and boldness among rural, urban, and migratory populations.

SOCIAL INFORMATION AND BIOLOGICAL INVASIONS: CHORUS SONGS ARE MORE ATTRACTIVE TO EUROPEAN STARLINGS IN MORE RECENTLY ESTABLISHED POPULATIONS.

The paper tests if recently established European starling populations are more responsive to social cues like chorus songs than long-established ones, finding they react more strongly to acoustic stimuli.

Large-scale topological disruption of chromosome territories 9 and 22 is associated with nonresponse to treatment in CML

The paper links structural disruption of chromosome territories 9 and 22 in CD34+ cells to TKI resistance in CML patients.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection

This study shows that CIGB-325, an anti-CK2 peptide, inhibits bovine coronavirus infection by reducing viral protein accumulation and cytopathic effects.

Retinoic acid exerts sexually dimorphic effects over muscle energy metabolism and function

This study shows that reduced retinoic acid (RA) in male mice impairs muscle metabolism and function, while female mice show improved metabolic outcomes due to estrogen-induced compensatory mechanisms.