Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance
A. B. Rovsing, E. A. Thomsen, I. Nielsen, T. W. Skov, Y. Luo, K. Dybkaer, J. G. Mikkelsen
This study identifies genes and pathways involved in vincristine resistance in DLBCL cells using CRISPR screening and shows synergistic effects of combining KIF18A inhibition with vincristine.
bioRxiv · Jan 19, 2023Cancer Biology