Cancer BiologybioRxiv
Acquired RAD51C promoter methylation loss causes PARP inhibitor resistance in high grade serous ovarian carcinoma
K. Nesic, O. Kondrashova, R. M. Hurley…·C. L. Scott
This study shows that loss of RAD51C promoter methylation leads to PARP inhibitor resistance in high-grade serous ovarian carcinoma, independent of BRCA1 methylation status.
DOI 10.1158/0008-5472.can-21-0774