Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study
S. Ghosh, G. Guglielmi, I. Orfanidis, F. Spill, A. Hickey, E. Hanssen, V. Rajagopal
This study uses computational modeling to show that disorganized mitochondrial and myofibrillar arrangement in diabetic cardiomyocytes leads to spatial variation in ADP/ATP ratios and increased inorganic phosphate concentration.
bioRxiv · May 22, 2022Cell Biology