Author

I. Pacheco-Leyva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. L. Pereira· 1 shared M. A. Araujo· 1 shared M. Baessa· 1 shared M. E. Futschik· 1 shared M. N. Ghezzo· 1 shared M. T. Fernandes· 1 shared N. L. Alves· 1 shared N. R. dos Santos· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

J. L. Pereira

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2 papers

Recent·Most cited

Transgenic αβ TCR tonic signaling is leukemogenic while strong stimulation is leukemia-suppressive

T. A. Catarino, I. Pacheco-Leyva, J. L. Pereira, M. Baessa, N. R. dos Santos

This study shows that transgenic β TCR expression in mice causes T-ALL, but strong TCR stimulation suppresses it, highlighting a dual role of TCR signaling in leukemia.

bioRxiv · Jan 17, 2024Cancer Biology

FoxN1-dependent thymic epithelial cells promote T-cell leukemia development

M. N. Ghezzo, M. T. Fernandes, R. S. Machado, I. Pacheco-Leyva, M. A. Araujo, R. K. R. Kalathur, M. E. Futschik, N. L. Alves, N. Rodrigues dos Santos

The paper identifies FoxN1-dependent thymic epithelial cells as promoters of T-cell leukemia development using a mouse model.

bioRxiv · Jan 11, 2018Cancer Biology