Dynamics and structural changes of calmodulin upon interaction with its potent antagonist calmidazolium
C. Leger, I. Pitard, M. Sadi, N. Carvalho, S. Brier, A. Mechaly, D. Raoux Barbot, M. Davi, S. Hoos, P. Weber, P. Vachette, D. Durand, A. Haouz, J. I. Guijarro, D. Ladant, A. CHENAL
This study characterizes the structural and dynamic changes in calmodulin upon binding to calmidazolium, revealing conformational shifts similar to those induced by peptide ligands.
bioRxiv · Jan 19, 2022 · PreprintBiophysics