A. Haouz

Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Interactions of the Protein Tyrosine Phosphatase PTPN3 with Viral and Cellular Partners through its PDZ Domain: Insights into Structural Determinants and Phosphatase Activity

This study investigates the interactions of PTPN3's PDZ domain with viral and cellular PBMs, revealing structural determinants and the inhibitory role of the PDZ domain on phosphatase activity.

Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation.

The paper identifies two new divisome members in Corynebacteriales and shows their role in coordinating cell division and polar elongation with the divisome and elongasome.

Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus.

This study shows that yellow fever virus pr retains high affinity for E at neutral pH, differing from other flaviviruses, and reveals a unique mechanism for pr release from mature particles.

A novel nuclease is the executing part of a bacterial plasmid defense system

The paper identifies MksG as a novel nuclease in the MksBEFG plasmid defense system of Corynebacterium glutamicum, showing it degrades plasmid DNA and is regulated by DivIVA.

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells

The paper determines the X-ray structure of a simian Foamy Virus receptor binding domain, revealing its fold and key residues involved in heparan sulfate interaction.

DNA-binding mechanism and evolution of Replication Protein A

This study characterizes the DNA-binding mechanism of RPA from Pyrococcus abyssi using crystal and cryo-EM structures, revealing conserved features and a novel archaeal-specific domain.

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

The paper determines the structure of the PulL-PulM heterodimer in the T2SS assembly platform and proposes a model for its dynamic role in pseudopilus polymerization.

Dynamics and structural changes of calmodulin upon interaction with its potent antagonist calmidazolium

This study characterizes the structural and dynamic changes in calmodulin upon binding to calmidazolium, revealing conformational shifts similar to those induced by peptide ligands.

Interactions of SARS-CoV-2 protein E with cell junctions and polarity PDZ-containing proteins

This study investigates how SARS-CoV-2 protein E interacts with PDZ-containing proteins involved in cell junctions and polarity, showing structural and functional differences between variants.

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

This study identifies how HHV-8 uses molecular mimicry of ephrin ligands to bind EphA2, triggering signaling that facilitates viral entry and cytoskeleton remodeling.

A high-affinity calmodulin-binding site in the CyaA toxin translocation domain is essential for invasion into eukaryotic cells

Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum

This study investigates the essential interaction between FtsZ and SepF in C. glutamicum, revealing their dynamic roles in Z-ring and septum formation through structural and functional analyses.

Crippling the bacterial cell wall molecular machinery

This study identifies the role of lytic transglycosylase LtgA in bacterial cell wall integrity and shows that targeting it can impair Neisseria meningitidis fitness during infection.