Deep Generative Design of Epitope-Specific Binding Proteins by Latent Conformation Optimization
R. R. Eguchi, C. A. Choe, U. Parekh, I. S. Khalek, M. D. Ward, N. Vithani, G. R. Bowman, J. G. Jardine, P. Huang
This paper introduces Sculptor, a deep generative algorithm for designing epitope-specific binding proteins by optimizing loop conformations and backbone structures.
bioRxiv · Dec 22, 2022 · PreprintBiochemistry