J. G. Jardine

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Deep Generative Design of Epitope-Specific Binding Proteins by Latent Conformation Optimization

This paper introduces Sculptor, a deep generative algorithm for designing epitope-specific binding proteins by optimizing loop conformations and backbone structures.

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

Structural basis of a public antibody response to SARS-CoV-2

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.