Author

I. Tzani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. Clarke· 4 shared N. Barron· 3 shared C. Gallagher· 2 shared J. Bones· 2 shared K. Motheramgari· 2 shared L. Zhang· 2 shared M. Castro Rivadeneyra· 2 shared R. Hagan· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

C. Clarke

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4 papers

Recent·Most cited

Understanding the transcriptional response to ER stress in Chinese hamster ovary cells using multiplexed single cell RNA-seq

M. Castro Rivadeneyra, I. Tzani, S. Boi, C. Clarke

This paper uses multiplexed scRNA-seq to study the transcriptional response of CHO cells to tunicamycin treatment and identifies gene modules associated with ER stress.

bioRxiv · Mar 31, 2022 · PreprintCell Biology

Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics

I. Tzani, N. Herrmann, S. Carillo, C. A. Spargo, R. Hagan, N. Barron, J. Bones, W. S. Dillmore, C. Clarke

The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.

bioRxiv · Nov 4, 2020Cell Biology

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

I. Tzani, C. Monger, K. Motheramgari, C. Gallagher, R. Hagan, P. Kelly, A. Costello, J. Meiller, P. Floris, L. Zhang, M. Clynes, J. Bones, N. Barron, C. Clarke

This study shows that reducing temperature induces widespread alternative splicing in CHO cells, with many events occurring in genes not detected by standard expression analysis.

bioRxiv · Dec 3, 2019Cell Biology

Expanding the Chinese hamster ovary cell long non-coding RNA transcriptome using RNASeq

K. Motheramgari, R. Valdes-Bango Curell, I. Tzani, C. Gallagher, M. Castro Rivadeneyra, L. Zhang, N. Barron, C. Clarke

This study expands the long non-coding RNA (lncRNA) transcriptome of Chinese hamster ovary (CHO) cells using RNASeq, doubling annotated lncRNA transcripts and identifying 1,000 new antisense lncRNAs.

bioRxiv · Dec 3, 2019Cell Biology