Author

R. Hagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Clarke· 2 shared I. Tzani· 2 shared J. Bones· 2 shared N. Barron· 2 shared A. Bera· 1 shared A. Costello· 1 shared A. Shah· 1 shared C. A. Spargo· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

C. Clarke

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

O. Del Rosario, K. Suresh, M. Kallem, G. Singh, A. Shah, Y. Xin, N. Philip, F. D'Alessio, M. Srivastava, A. Bera, L. Shimoda, M. Merchant, M. Rane, C. Machamer, J. Mock, , M. Damarla

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

bioRxiv · Nov 30, 2021 · PreprintCancer Biology

Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics

I. Tzani, N. Herrmann, S. Carillo, C. A. Spargo, R. Hagan, N. Barron, J. Bones, W. S. Dillmore, C. Clarke

The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.

bioRxiv · Nov 4, 2020Cell Biology

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

I. Tzani, C. Monger, K. Motheramgari, C. Gallagher, R. Hagan, P. Kelly, A. Costello, J. Meiller, P. Floris, L. Zhang, M. Clynes, J. Bones, N. Barron, C. Clarke

This study shows that reducing temperature induces widespread alternative splicing in CHO cells, with many events occurring in genes not detected by standard expression analysis.

bioRxiv · Dec 3, 2019Cell Biology