De novo designed protein enables precise epitope-level control of Gremlin-1 antagonism
Bunia I. Adsersen, Cecilie M. Møller-Jensen, Christian P. Jacobsen, Tanja Domeyer, Johannes R. Loeffler, Monica L. Fernandez-Quintero, Iacopo Tomberli, Astrid B. Jensen, Mikkel S. Jakobsen, Sandhya Bangaru, Andrew Ward, Esperanza Rivera‐de‐Torre, Stefán B. Gunnarsson, Andreas Hald, Timothy P. Jenkins
This study designs a protein that precisely controls Gremlin-1 antagonism by releasing BMPs, revealing the role of interface rigidity in antagonist function.
bioRxiv · Dec 18, 2025 · PreprintBiochemistry