Andreas Hald

This paper presents a rapid, automation-friendly pipeline for characterizing de novo protein binders without cell culture or purification, achieving binding affinity and kinetics in three days.

This paper introduces Proton-PottsMPNN, a model that designs pH-sensitive binders by explicitly modeling protonation states, resulting in pH-dependent PD-L1 binders with transition pH values between 4.0 and 5.8.

This study designs a protein that precisely controls Gremlin-1 antagonism by releasing BMPs, revealing the role of interface rigidity in antagonist function.

This study evaluates Gremlin-1 as a therapeutic target in MASH fibrosis, finding it upregulated but not amenable to targeting due to its restricted expression and lack of effect on fibrogenesis.