Christian P. Jacobsen

This paper introduces Proton-PottsMPNN, a model that designs pH-sensitive binders by explicitly modeling protonation states, resulting in pH-dependent PD-L1 binders with transition pH values between 4.0 and 5.8.

This study designs de novo single-domain antibodies against cobra neurotoxin and shows they protect mice from lethal venom toxicity.

This study designs a protein that precisely controls Gremlin-1 antagonism by releasing BMPs, revealing the role of interface rigidity in antagonist function.

The paper analyzes 3,766 binders to identify predictive features for experimental success in de novo binder design, showing that AF3-derived metrics improve prediction accuracy.