Neurotrauma-induced vulnerability of C9orf72 ALS iPSC-motor neurons revealed by biofidelic stretch injury
Eric J. Martin, Catrina Reyes, Angela Mitevska, Citlally Santacruz, Francesco Alessandrini, Ian E. Jones, Gopinath Krishnan, Gerard Esteruelas, Fen‐Biao Gao, John D. Finan, Evangelos Kiskinis
This study shows that C9orf72 ALS patient motor neurons are more vulnerable to trauma, with TDP-43 mislocalization and reduced recovery after repeated mild injuries.
bioRxiv · Mar 21, 2024 · PreprintNeuroscience