Author

Francesco Alessandrini

Northwestern UniversityORCID 0000-0002-8450-848XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Evangelos KiskinisiD· 2 shared Angela MitevskaiD· 1 shared Catrina Reyes· 1 shared Citlally Santacruz· 1 shared Eric J. Martin· 1 shared Fen‐Biao GaoiD· 1 shared Gerard EsteruelasiD· 1 shared Gopinath KrishnaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Evangelos KiskinisORCID

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2 papers

Recent·Most cited

Neurotrauma-induced vulnerability of C9orf72 ALS iPSC-motor neurons revealed by biofidelic stretch injury

Eric J. Martin, Catrina Reyes, Angela Mitevska, Citlally Santacruz, Francesco Alessandrini, Ian E. Jones, Gopinath Krishnan, Gerard Esteruelas, Fen‐Biao Gao, John D. Finan, Evangelos Kiskinis

This study shows that C9orf72 ALS patient motor neurons are more vulnerable to trauma, with TDP-43 mislocalization and reduced recovery after repeated mild injuries.

bioRxiv · Mar 21, 2024 · PreprintNeuroscience

ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length

Francesco Alessandrini, Matthew Wright, Tatsuaki Kurosaki, Lynne E. Maquat, Evangelos Kiskinis

The paper identifies UPF1 targets in motor neurons and shows TDP-43 dysfunction disrupts UPF1-mediated mRNA surveillance and 3'UTR regulation in ALS.

bioRxiv · Jan 31, 2024 · PreprintNeuroscience