Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with signatures from post mortem adult brains
Gabriel E. Hoffman, Brigham J. Hartley, Erin K. Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith L. Rapoport, Pamela B. Sklar, Kristen Brennand
The paper identifies concordant transcriptional signatures of schizophrenia in hiPSC-derived neurons and post mortem brains, suggesting neurons better model genetic risk and recommends increasing cohort size in hiPSC studies.
Nature Communications · Dec 14, 2017Peer-reviewedGenetics