Author

Brigham J. Hartley

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:imaging· 1

Frequent Co-Authors

Kristen BrennandiD· 2 shared Aaron TopoliD· 1 shared Ahmed Sandakli· 1 shared Aidan H. McMorrowiD· 1 shared Ajamete KaykasiD· 1 shared Alison GoateiD· 1 shared Angela Oliveira PiscoiD· 1 shared Anna A. PimenovaiD· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Kristen BrennandORCID

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4 papers

Recent·Most cited

A repository of Ogden syndrome (NAA10) and NAA15 patient derived iPSC lines and isogenic pairs by X-chromosome screening and genome-editing.

Josephine Wesely, Tom Rusielewicz, Yu-Ren Chen, Brigham J. Hartley, Dayna McKenzie, Matthew Yim, Colin T. Maguire, Ryan D. Bia, Sarah Franklin, Rikhil Makwana, Elaine J. Marchi, Manali Nikte, Soha Patil, Maria L. Sapar, Dorota N. Moroziewicz, , Gholson J. Lyon

The paper describes the generation and characterization of patient-derived iPSC lines and isogenic pairs for Ogden syndrome, including CRISPR corrections and X-chromosome screening.

bioRxiv · Sep 28, 2024 · PreprintGenetics

Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes

Rahul Atmaramani, Tommaso Dreossi, Kevin Ford, Lin Gan, Jana M. Mitchell, Shengjiang Tu, Jeevaa Velayutham, Haoyang Zeng, Michael Chickering, Tom Soare, Srinivasan Sivanandan, Ryan Conrad, Yujia Bao, Santiago Akle, Jonathan Liu, , Samuel Sances

The paper uses deep learning on images of iPSC-derived motor neurons with fALS mutations to identify disease-relevant phenotypes and molecular differences.

bioRxiv · Jan 4, 2024 · PreprintNeuroscience

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with signatures from post mortem adult brains

Gabriel E. Hoffman, Brigham J. Hartley, Erin K. Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith L. Rapoport, Pamela B. Sklar, Kristen Brennand

The paper identifies concordant transcriptional signatures of schizophrenia in hiPSC-derived neurons and post mortem brains, suggesting neurons better model genetic risk and recommends increasing cohort size in hiPSC studies.

Nature Communications · Dec 14, 2017Peer-reviewedGenetics

An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells

Julia TCW, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M M. Karch, Hemali P. Phatnani, Paul A. Slesinger, Bin Zhang, Alison Goate, Kristen Brennand

The paper describes a method to generate highly pure astrocytes from hiPSCs, showing they resemble primary astrocytes and have functional properties relevant to neurological disorders.

Stem Cell Reports · Jul 27, 2017Peer-reviewedNeuroscience