Kristen Brennand

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

The paper identifies a pro-plasticity program in spared corticospinal neurons after partial CNS injury and validates strategies to enhance neurite regeneration.

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

The paper investigates how maternal and fetal immune activation interacts with genetic risk profiles to influence neuronal regulatory activity and psychiatric traits.

The paper investigates how POGZ loss-of-function affects transcription factor binding and gene expression in neurons, revealing shared molecular changes with other NDD-related genes.

The paper identifies glial cell-specific regulatory elements and genetic risk modifiers in tau-related dementias using single-nucleus epigenomic profiling.

The paper maps R-loop landscapes in the developing human brain and shows their role in neural differentiation and gene expression programs.

The paper identifies convergent coexpressed genes shared between common and rare variant risk genes in six neuropsychiatric disorders, revealing shared biological mechanisms and therapeutic targets.

This study uses a 2D stretch injury model to show that mechanical stretch disrupts calcium dynamics, mitochondrial function, and Piezo1 distribution in human astrocytes, with temporary effects at moderate injury severity.

This study shows BRD1 haploinsufficiency disrupts early neuronal programming and synaptic maturation in human induced glutamatergic neurons, leading to altered neurodevelopmental trajectories and increased neuronal activity.

The paper develops an integrative sequencing strategy to catalog NRXN1 isoforms across human brain tissues and hiPSC organoids, revealing cell-type-specific splicing patterns and therapeutic potential of ASO targeting.

The paper identifies regulatory variants associated with Alzheimer's disease in human microglia using MPRA and highlights differences in variant activity between cell sources.

This study identifies pathway-level polygenicity in anorexia nervosa by constructing pathway-based polygenic risk scores and finding 497 associated pathways.

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

This study investigates the phenotypic complexities of rare heterozygous NRXN1 deletions, showing cell-type-specific synaptic effects through LOF and GOF mechanisms, highlighting the need for precision medicine strategies.

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

This study uses single-nucleus RNA sequencing to analyze periventricular white matter in vascular dementia, identifying increased heat shock protein responses as a conserved feature across cell types.

The paper identifies BMI-dynamic gene expression loci in the brain and gut, showing how BMI interacts with genetic variants to influence gene expression and disease-related pathways.

The paper investigates transcriptional signatures of trauma in human brain regions using RNA-seq data from 304 donors, identifying differential vulnerability of cortical and amygdala regions to different trauma types.

This study identifies convergent biological pathways in mature neurons affected by neurodevelopmental disorder risk genes and shows drug candidates can ameliorate behavioral phenotypes.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

MASTR-seq enables cost-effective, high-throughput, and accurate measurement of STR length and DNA methylation at single-allele resolution using nanopore sequencing.

The paper identifies stress-interactive eQTLs that dysregulate gene expression in the brain under stress, uncovering novel genes linked to brain disorder risk in traumatic stress contexts.

The paper profiles gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 developmental timepoints to study cell fate determination and neuropsychiatric disease mechanisms.

This study investigates the 3D genome organization in human brain development, finding differences in compartment and loop domain formation between neurons and glia.

The paper maps 3D chromatin structures in neuronal subtypes and shows how schizophrenia risk loci reorganize during differentiation, linking regulatory loops to gene function.