Structural Analysis of Recombinant AAV Vector Genomes at Single-Molecule Resolution
David Rouleau, Dimpal Lata, Serena Dollive, Robert E. Bruccoleri, Laura P. van Lieshout, Diane Golebiowski, Ify Iwuchukwu
The paper develops a pipeline to classify AAV genome structures at single-molecule resolution using long-read sequencing, revealing structural heterogeneity and its contributing factors.
PLoS ONE · Jul 30, 2026Peer-reviewedBioinformatics