Author

David Rouleau

Oxford BioMedica (United Kingdom)ORCID 0009-0008-9603-0605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Assay:long-read sequencing· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Dimpal LataiD· 2 shared Robert E. BruccoleriiD· 2 shared Serena Dollive· 2 shared Celia Slater· 1 shared Christopher Phillion· 1 shared Diane GolebiowskiiD· 1 shared Ify Iwuchukwu· 1 shared Kiran AdhikariiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Dimpal LataORCID

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2 papers

Recent·Most cited

BioinformaticsPLoS ONEPeer-reviewedJul 30, 2026

Structural Analysis of Recombinant AAV Vector Genomes at Single-Molecule Resolution

David Rouleau, Dimpal Lata, Serena Dollive…·Ify Iwuchukwu

The paper develops a pipeline to classify AAV genome structures at single-molecule resolution using long-read sequencing, revealing structural heterogeneity and its contributing factors.

DOI 10.1371/journal.pone.0339201

long-read sequencingstatistical model

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BioinformaticsbioRxivPreprintJul 25, 2025

The Tiling Algorithm - A general method for structural characterization of accurate long DNA sequence reads: application to AAV genome sequences.

Robert E. Bruccoleri, David Rouleau, Celia Slater…·Serena Dollive

The paper introduces a tiling algorithm to accurately characterize structural features of AAV genomes, demonstrating its effectiveness across multiple datasets.

DOI 10.1101/2025.07.25.666743

long-read sequencingexperimental assay

𝕏 PostBluesky