Mitochondrial dysfunction in Machado Joseph disease: insights from a multi-model system
Ignacio Simo, Katherine J. Robinson, Julia Y. Kam, Andrea Kuriakose, Esmeralda Parić, Flora Cheng, Anastasiya Potapenko, Yousun An, Albert Lee, Angela S. Laird
This study investigates mitochondrial dysfunction in Machado Joseph disease using multiple models, finding impaired oxidative phosphorylation and altered mitochondrial morphology in mice and zebrafish.
bioRxiv · May 1, 2025 · PreprintNeuroscience