Flora Cheng

The paper compares proteostasis capacity in two neuronal cell lines by analyzing inclusion formation of an aggregation-prone protein, revealing differences in proteostasis machinery engagement.

This study investigates mitochondrial dysfunction in Machado Joseph disease using multiple models, finding impaired oxidative phosphorylation and altered mitochondrial morphology in mice and zebrafish.

This study shows that sodium butyrate improves symptoms of SCA3 by enhancing autophagy through PKA/AMPK signaling in both cell and zebrafish models.

The paper identifies cyclin F interactors using BioID and shows that ALS/FTD-associated cyclin F mutations disrupt paraspeckle protein homeostasis, particularly RBM14 levels in patient tissue.