Julia Y. Kam

Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease

This study shows that gut microbiome changes and colonic dysfunction occur before motor impairments in MJD mice, suggesting inflammation and endocrine factors may link gut and brain in disease progression.

Mitochondrial dysfunction in Machado Joseph disease: insights from a multi-model system

This study investigates mitochondrial dysfunction in Machado Joseph disease using multiple models, finding impaired oxidative phosphorylation and altered mitochondrial morphology in mice and zebrafish.