Author

Igor S. Tolokh

Virginia Tech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Organism:Drosophila· 3 Assay:Hi-C· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexey V. OnufrieviD· 3 shared Igor V. SharakhoviD· 2 shared Erik Cross· 1 shared Junkai ZhangiD· 1 shared Nicholas Allen KinneyiD· 1 shared Samira MaliiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 8 mutual co-author links

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3 shared papersGenomics

Alexey V. OnufrievORCID

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3 papers

Recent·Most cited

Reversing aging-like 3D genome disorganization in a Drosophila interphase model

Alexey V. Onufriev, Junkai Zhang, Igor V. Sharakhov, Igor S. Tolokh

The paper investigates the reversal of aging-like 3D genome disorganization in Drosophila by restoring lamina-associated domain interactions.

bioRxiv · Oct 8, 2026 · PreprintGenomics

Quantifying Conformational Heterogeneity of 3D Genome Organization in Fruit Fly

Samira Mali, Igor S. Tolokh, Erik Cross, Alexey V. Onufriev

The paper quantifies cell-to-cell conformational heterogeneity of 3D chromatin structures in fruit fly using a new metric and compares models based on different Hi-C data types.

PLoS ONE · Jul 3, 2025Peer-reviewedGenomics

Strong interactions between highly-dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Igor S. Tolokh, Nicholas Allen Kinney, Igor V. Sharakhov, Alexey V. Onufriev

The paper develops a dynamical model of Drosophila nuclei to study how LAD-NE interactions and TAD dynamics shape chromatin structure.

bioRxiv · Jan 28, 2022 · PreprintGenomics