JAK Inhibitor Withdrawal Causes a Transient Proinflammatory Cascade: A Potential Mechanism for Major Adverse Cardiac Events
Ilya Gurevic, Loïc Meudec, Xavier Mariette, Gaëtane Nocturne, Sara S. McCoy
This study shows that stopping Type I JAK inhibitors leads to a temporary pro-inflammatory response, which may explain some cardiac issues linked to JAK inhibitor use.
PLoS ONE · Jun 16, 2025Peer-reviewedImmunology