CYP3A5 inhibition causes G1/S blockade and synergizes with CDK4/6 inhibitor to suppress prostate cancer cell growth: Implications in reducing health disparity
Jeetesh Sharma, Imran K. Mohammed, Richard L. Tillett, Jake McLean, Shirley Shen, Ajay P. Singh, Oscar B. Goodman, Edwin C. T. Oh, Ranjana Mitra
This study shows that inhibiting CYP3A5 blocks the cell cycle and synergizes with CDK4/6 inhibitors to suppress prostate cancer growth, particularly in African-American patients.
bioRxiv · Oct 1, 2024 · PreprintCancer Biology