Author

Jake McLean

Roseman University of Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay P. SinghiD· 1 shared Edwin C. T. OhiD· 1 shared Imran K. Mohammed· 1 shared Jeetesh SharmaiD· 1 shared Oscar B. GoodmaniD· 1 shared Ranjana MitraiD· 1 shared Richard L. TillettiD· 1 shared Shirley Shen· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Ajay P. SinghORCID

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1 paper

Recent·Most cited

CYP3A5 inhibition causes G1/S blockade and synergizes with CDK4/6 inhibitor to suppress prostate cancer cell growth: Implications in reducing health disparity

Jeetesh Sharma, Imran K. Mohammed, Richard L. Tillett, Jake McLean, Shirley Shen, Ajay P. Singh, Oscar B. Goodman, Edwin C. T. Oh, Ranjana Mitra

This study shows that inhibiting CYP3A5 blocks the cell cycle and synergizes with CDK4/6 inhibitors to suppress prostate cancer growth, particularly in African-American patients.

bioRxiv · Oct 1, 2024 · PreprintCancer Biology