Aberrant brain-type neuronal programs in large-cell pancreatic neuroendocrine carcinoma
Olivia Debnath, Hilmar Berger, Katharina M Detjen, Philipp Kirchner, Ilaria Marinoni, Ines Eichhorn, Felix Bolduan, Thomas Conrad, David A. Horst, Roland Eils, Bertram J. Wiedenmann, Aurel A. Perren, Naveed Ishaque
The paper identifies two neuroendocrine cell states in large-cell pancreatic neuroendocrine carcinoma using single-nucleus transcriptomics, revealing an aberrant brain-type neuronal program and a stress-responsive state.
Communications Biology · Jul 30, 2026Peer-reviewedCancer Biology