Thomas Conrad

This study identifies Apold1 as a key regulator of glomerular endothelial regeneration using single-cell RNA sequencing and spatial transcriptomics in a mouse model.

The paper identifies tumor-reactive TCRs using T/N ratios and validates them with single-cell and spatial data, showing their tumor association and effector phenotype.

The paper identifies two neuroendocrine cell states in large-cell pancreatic neuroendocrine carcinoma using single-nucleus transcriptomics, revealing an aberrant brain-type neuronal program and a stress-responsive state.

This study identifies distinct immune mechanisms in pancreatic inflammation during metabolic stress and aging using spatial and single-cell analyses.

The paper introduces circVDJ-seq for efficient T cell receptor profiling from single-cell and spatial multi-omics data, revealing distinct immune microenvironments and T cell clonality patterns in various clinical contexts.

The paper shows that EMT in BRCA1 carriers leads to precancerous states through morphological, transcriptomic, and functional changes.

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

This study uses human hair-bearing skin organoids to investigate HSV-1 infection and host responses, revealing cell-type-specific susceptibility and spatially organized immune reactions.

This study investigates the role of osteopontin (SPP1/OPN) in colitis-associated carcinoma (CAC) using a multi-omics approach, revealing its indirect immunosuppressive role in the tumor microenvironment.

VoltRon is an R package for spatial omics analysis that integrates multi-resolution and multi-omics data through image registration and spatial alignment.

This study identifies SORCS2's role in pancreatic islet stress response, showing its importance in glucose-stimulated insulin release and metabolic health.

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

This paper presents a high-sensitivity targeted method to measure pri-miRNA processing efficiency in clinical samples and identifies 24 microRNAs with significant changes in processing efficiency between normal liver and hepatocellular carcinoma.

The paper investigates the role of m6A in splicing efficiency by analyzing nascent RNA transcripts and shows that early m6A deposition accelerates splicing.