A soluble host signal drives rapid, brain-predominant capsular thickening in Streptococcus pneumoniae via a putative sodium-dependent transporter (SPD_0642) and capsular prepromoter sequence
Никола Томов, Sabrina Hupp, Annelies Müller, Dario Baronti, Janine Lux, Irene Trillo, Cebile Natasha Lekhuleni, Tim van Opijnen, Federico Rosconi, Anne von Gottberg, Lucy Jane Hathaway, Asparouh I. Iliev
This paper identifies a host-derived signal that induces rapid, tissue-specific capsule thickening in Streptococcus pneumoniae, independent of phase variation, and shows two genetic determinants involved in this process.
bioRxiv · Mar 30, 2026 · PreprintMicrobiology