Divergent spontaneous antibiotic-resistance evolution confers reciprocal and exploitable collateral sensitivity effects
Apostolos Liakopoulos, Sebastian Tommi Tandar, Irene V Hoogendijk, Efthymia Fragkiskou, Zheren Zhang, Bastienne Vriesendorp, Linda B. S. Aulin, J. G. Coen van Hasselt, Daniel E. Rozen
This study identifies consistent collateral sensitivity interactions between antibiotics in S. pneumoniae and develops a model to guide treatment strategies.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology