Author

Irune Calzado Lopez

University of the Basque Country

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Iraia Muñoa-HoyosiD· 3 shared Manu AraolazaiD· 3 shared Mikel AlbizuriiD· 3 shared Nerea SubirániD· 3 shared Ainize Odriozola LarrañagaiD· 1 shared Iratxe Ajuria-MorentiniD· 1 shared Paloma GarcíaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 19 mutual co-author links

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3 shared papersPhysiology

Iraia Muñoa-HoyosORCID

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3 papers

Recent·Most cited

Lipidomic and metabolomic profiling on low count human spermatozoa: A robust and reproducible method for untargeted HPLC-ESI-MS/MS-based approach

Irune Calzado Lopez, Manu Araolaza, Mikel Albizuri, Ainize Odriozola Larrañaga, Iraia Muñoa-Hoyos, Iratxe Ajuria-Morentin, Nerea Subirán

This paper develops a sensitive untargeted HPLC-ESI-MS/MS workflow for lipidomic and metabolomic profiling of human spermatozoa using only 1.25 million cells, revealing interconnected lipid and metabolic pathways.

Cells · Apr 5, 2026Peer-reviewedPhysiology

Chronic morphine treatment induces a conserved Smchd1-dependent epigenetic memory that disrupts X-chromosome inactivation and genomic imprinting

Iraia Muñoa-Hoyos, Manu Araolaza, Irune Calzado Lopez, Mikel Albizuri, Paloma García, Nerea Subirán

This study shows chronic morphine exposure represses Smchd1, disrupting X-chromosome inactivation and genomic imprinting through epigenetic changes in mouse and human cells.

bioRxiv · Mar 25, 2026 · PreprintDevelopmental Biology

A Comparative Assessment of edgeR and methylKit Pipelines for DNA Methylation Detection

Iraia Muñoa-Hoyos, Manu Araolaza, Irune Calzado Lopez, Mikel Albizuri, Nerea Subirán

This study compares edgeR and methylKit for detecting differentially methylated cytosines in mouse embryonic stem cells after morphine exposure, finding moderate concordance and highlighting the need for integrated analysis.

bioRxiv · May 11, 2025 · PreprintBioinformatics