Author

Manu Araolaza

University of the Basque CountryORCID 0000-0003-1838-4594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:DNA methylation· 3 Organism:mouse· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Iraia Muñoa-HoyosiD· 4 shared Nerea SubirániD· 4 shared Irune Calzado Lopez· 3 shared Mikel AlbizuriiD· 3 shared Ainize Odriozola LarrañagaiD· 1 shared Iratxe Ajuria-MorentiniD· 1 shared Irune CalzadoiD· 1 shared Itziar Urizar‐ArenazaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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4 shared papersDevelopmental Biology

Iraia Muñoa-HoyosORCID

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4 papers

Recent·Most cited

PhysiologyCellsPeer-reviewedApr 5, 2026

Lipidomic and metabolomic profiling on low count human spermatozoa: A robust and reproducible method for untargeted HPLC-ESI-MS/MS-based approach

Irune Calzado Lopez, Manu Araolaza, Mikel Albizuri…·Nerea Subirán

This paper develops a sensitive untargeted HPLC-ESI-MS/MS workflow for lipidomic and metabolomic profiling of human spermatozoa using only 1.25 million cells, revealing interconnected lipid and metabolic pathways.

DOI 10.3390/cells15070649

humanmetabolomics

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Developmental BiologybioRxivPreprintMar 25, 2026

Chronic morphine treatment induces a conserved Smchd1-dependent epigenetic memory that disrupts X-chromosome inactivation and genomic imprinting

Iraia Muñoa-Hoyos, Manu Araolaza, Irune Calzado Lopez…·Nerea Subirán

This study shows chronic morphine exposure represses Smchd1, disrupting X-chromosome inactivation and genomic imprinting through epigenetic changes in mouse and human cells.

DOI 10.64898/2026.03.23.713629

mousehuman

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Developmental BiologyInternational Journal of Molecular SciencesPeer-reviewedJul 22, 2025

Chronic morphine treatment leads to a global DNA hypomethylation via active and passive demethylation mechanisms in mESCs

Manu Araolaza, Iraia Muñoa-Hoyos, Itziar Urizar‐Arenaza…·Nerea Subirán

3 citations

mouseDNA methylation

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BioinformaticsbioRxivPreprintMay 11, 2025

A Comparative Assessment of edgeR and methylKit Pipelines for DNA Methylation Detection

Iraia Muñoa-Hoyos, Manu Araolaza, Irune Calzado Lopez…·Nerea Subirán

This study compares edgeR and methylKit for detecting differentially methylated cytosines in mouse embryonic stem cells after morphine exposure, finding moderate concordance and highlighting the need for integrated analysis.

DOI 10.1101/2025.05.11.653026

mouseDNA methylation

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