Cyst-type epithelial heterogeneity shapes therapeutic responsiveness in ADPKD
Johannes Roeles, Axel Giesler, Jessica Schmitz, Johannes Koenig, Frank Friedersdorff, Jonas Busch, Robert Greite, Matteus Krappitz, Isabel A. Layne, Michael Köttgen, Wolfgang E. Kuehn, Jessica Schmid, Katharina Schmidt, Konrad Hoeft, Rafael Kramann, , Christian Hinze
The paper identifies three epithelial cyst types in ADPKD using single-nucleus RNA sequencing and machine learning, showing their association with therapeutic response.
bioRxiv · May 12, 2026 · PreprintMolecular Biology