Jan Hinrich Braesen

Cyst-type epithelial heterogeneity shapes therapeutic responsiveness in ADPKD

The paper identifies three epithelial cyst types in ADPKD using single-nucleus RNA sequencing and machine learning, showing their association with therapeutic response.

Integrated kidney and urine proteomics define encrypted antimicrobial peptides as effectors of host defence in human pyelonephritis

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD

This study shows BICC1 interacts with PKD1 and PKD2, exacerbating ADPKD severity through RNA metabolism, using animal models, genetic studies, and human cohorts.

Interleukin enhancer binding factor 2 (Ilf2) and kidney epithelial stress resilience

This study identifies Ilf2 as a key regulator of kidney epithelial stress resilience through transcriptional and splicing programs in cultured cells and mouse models.

Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling

This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.