BiochemistryAnalytical ChemistryPeer-reviewed
Enzymatic Ligation Strategy to Enhance Electrospray Ionization Efficiency and Liquid Chromatography-Mass Spectrometry of DNA and RNA Oligonucleotides
Max D. Sharin, Nina J. Fitzgerald, Stephen M. Kennedy…·Kevin D. Clark
This paper introduces an enzymatic ligation strategy to enhance MS detection of RNA oligonucleotides by attaching signal enhancers, improving sensitivity and LC retention.
DOI 10.1021/acs.analchem.6c02458